![]() aureus POW infections - University of Iowa Prospective, randomized, double-blind placebo-controlled N=3966 patients at U of Iowa Preop carriage of S. Timing of Prophylactic Antibiotics and Risk of Surgical Wound Infection Prospective cohort 2847 patients clean/clean-contaminated sgy Timing SWI Early prep (364) -ē.8% Preop (1709) - 0.6% Periop (282) -đ.4% Postop (488) -ē.3% Classen et al NEJM 1992 326:281-6 ![]() ![]() Influence of Shaving on POW Infection Rates Rate (%) 9 10 8 3.5 - razor - clipper - Alexander et al Arch Sgy 1983 Relationship Between Wound Infection Reporting and Subsequent Infection Rates N=(1500) (1447) (1743) (1939) Cruse Canad Med Assoc J 1970 102: 251 % Pre Post Pre Post Hospital A Hospital B Surgical Site Infections in Presence or Absence of a Remote Infection 32% no yes 25% 18% 15% rate 10% 7% 6% Ann surg 1964 160 Surgical Site Infection 920,000 pts/23 million ops 14% adverse events in hospitals 18% (165,000) - disability > 6 months Double postop stay > $1.5 Billion in direct costs Crude rate Wenzel NEJM 1992 326:337-9 3% 4% 9% Clean Clean- Contam contam ![]()
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